Factors of Recurrence and Prevision in Polypous Rhinosinusitis
Published: 2026-04-12 · Issue: 2026 · Volume 1 · Issue 2
Abstract
This article analyzes the factors leading to the recurrence of the disease in polypoid rhinosinusitis and clinical and pathogenetic indicators of prognostic significance. The dissertation sets the tasks of assessing the course and recurrence of polypoid rhinosinusitis by determining the mucociliary clearance of the nasal cavity, predicting the development and recurrence of the disease by studying the levels of p53, EGF, VEGF, and VEGFR-2 in polypoid tissue and blood serum, as well as extending the duration of relapse through complex treatment. As a scientific novelty, it has been proven that a decrease in the mucociliary transport function of the nasal mucosa worsens the course of the disease, changes in the levels of p53, EGF, VEGF and VEGFR-2 are a determining factor in the course and development of polypoid rhinosinusitis, and the normalization of the level of cytokines in blood serum prolongs the period of relapse. The article analyzes the functional, morphological, immunobiological, and clinical factors leading to relapse in polypoid rhinosinusitis, and substantiates that their comprehensive assessment makes it possible to better determine the prognosis of the disease. It was concluded that early detection of the risk of recurrence is important for the correct choice of complex treatment tactics, determining the frequency of observation, and forming an individual preventive approach.
Keywords
polypoid rhinosinusitis, recurrence, prognosis, mucociliary transport, VEGF, EGF, p53, VEGFR-2, cytokines.