Diagnostic Significance of VEGF, EGF, P53, and VEGFR-2 Biomarkers in Polypotic Rhinosinusitis
Published: 2026-04-12 · Issue: 2026 · Volume 1 · Issue 2
Abstract
This article analyzes the diagnostic significance of biomarkers associated with angiogenesis, cell proliferation, and apoptosis processes in polypoid rhinosinusitis - VEGF, EGF, p53, and VEGFR-2. In the dissertation, in order to improve the diagnosis of polypoid rhinosinusitis, it was shown that by determining the content of p53 protein, EGF, VEGF, and VEGFR-2 in the polyp tissue and blood serum, their specificity for the disease and their relationship with etiopathogenesis were studied. Also, as a scientific novelty, it has been proven that changes in the amount of these biomarkers are a determining factor in the course and development of polypoid rhinosinusitis. The article extensively covers the role of these biomarkers in changes in polyp tissue and blood serum, their role in inflammatory, edematous, angiogenous, and reconstructive processes in the mucous membrane, and their significance in the clinical course, recurrence, and choice of treatment tactics. The role of VEGF and VEGFR-2 in angiogenesis, EGF in epithelial growth and regeneration, p53 in the control of apoptosis and the cell cycle were assessed as important links in the pathogenesis of polypoid rhinosinusitis. It was concluded that a comprehensive study of biomarkers is important for early diagnosis of the disease, assessment of clinical severity, prediction of the risk of recurrence, and control of the effectiveness of complex treatment.
Keywords
polypoid rhinosinusitis, VEGF, EGF, p53, VEGFR-2, biomarker, angiogenesis, diagnosis, prognosis.